Cinnamic acids and derivatives
AdipoGen Curcumin
Chemical. CAS 458-37-7. Formula C21H20O6. MW 368.38. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor activities. It interferes with multiple cell signaling pathways, including cell cycle cyclin D1 and cyclin E, apoptosis activation of caspases and down-regulation of anti-apoptotic gene products, proliferation HER-2, EGFR and AP-1, survival PI3K/AKT pathway, invasion MMP-9 and adhesion molecules, angiogenesis VEGF, metastasis CXCR-4, tumorigenesis and development Shh, Gli, metabolism PPARgamma, Nrf2, epigenetics HDACs, HATs, DNA methyltransferase I and microRNAs and inflammation NLRP3, TLR4, NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX.
Accela Chembio Inc 4-bromocinnamic Acid | Predominantly Trans | 100g | 1200-07-3 | MFCD00004394 | 97+% | Shelf Life: 1260 Days | Light Sensitive
4-bromocinnamic Acid | Predominantly Trans | 100g | 1200-07-3 | MFCD00004394 | 97+% | Shelf Life: 1260 Days | Light Sensitive
eMolecules Ambeed / 3-Bromo-4-fluorocinnamic acid / 1g / 527443839 / A579591 / / 160434-49-1 / MFCD00143095 / 245.047 / C9H6BrFO2
Ambeed / 3-Bromo-4-fluorocinnamic acid / 1g / 527443839 / A579591 / / 160434-49-1 / MFCD00143095 / 245.047 / C9H6BrFO2
Sigma Aldrich Fine Chemicals Biosciences trans-Cinnamic acid-beta,2,3,4,5,6-d6 98 atom % D | 91453-04-2 | MFCD01863724 | 250MG
trans-Cinnamic acid-beta,2,3,4,5,6-d6 98 atom % D | Mol Wt: 154.2 | 91453-04-2 | MFCD01863724 | 250MG
Medchemexpress LLC MRL-494 hydrochloride | 2699937-04-5 | 98.6% | 50 MG
MRL-494 hydrochloride is an antibacterial agent that functions as an inhibitor of β-barrel assembly machine A (BamA), making it impervious to efflux and the outer membrane permeability barrier. It is effective against both Gram-positive and Gram-negative bacteria, with an MIC of 12.5 μM for *Staphylococcus aureus* COL and 25 μM for *E. coli* JCM158.
- Inhibits β-barrel assembly machine A (BamA)
- Impervious to efflux and the outer membrane permeability barrier
- Exhibits strong activity against both Gram-positive and Gram-negative bacteria
- Lethally disrupts the cytoplasmic membrane
- Inhibits outer membrane proteins (OMPs) biogenesis
Indofine Chemical Ferulic Acid, 99%, 25 Gm
FERULIC ACID 25 GM, Rare Organics & Biochemicals, 4-Hydroxy-3-methoxycinnamic acid, C10H10O4, MW: 194.19, 0.99, 1135-24-6, MFCD00004400
Accela Chembio Inc 4-hydroxy-3 | 5-dimethoxycinnamic Acid | Predominantly Trans | 100g | 530-59-6 | MFCD00004401 | 97+% | Shelf Life: 1080 Days | Light Sensitive
4-hydroxy-3 | 5-dimethoxycinnamic Acid | Predominantly Trans | 100g | 530-59-6 | MFCD00004401 | 97+% | Shelf Life: 1080 Days | Light Sensitive
Medchemexpress LLC 4-chlorocinnamic acid | 1615-02-7 | MFCD00004396 | 100.0% | 182.61 g/mol | C9H7ClO2 | 25g
4-Chlorocinnamic acid is a derivative of Cinnamic acid (HY-N0610A) 4-Chlorocinnamic acid inhibits the monophenolase and diphenolase activities of mushroom tyrosinase with IC50 values of 0 477 mM and 0 229 mM respectively 4-Chlorocinnamic acid inhibits the mycelial growth of Colletotrichum gloeosporioides 4-Chlorocinnamic acid exhibits anticonvulsant activity against acute epilepsy induced by pentylenetetrazol[1][2][3][4]
Apexbio Technology LLC Curcumin(Synonyms: Diferuloylmethane, Turmeric yellow, Natural yellow 3, CI 75300), 100mg, CAS: 458-37-7.
Curcumin (CAS 458-37-7) is a natural small molecule known to inhibit tyrosinase activity with an IC50 of 47 M It modulates multiple signaling pathways involved in tumorigenesis and inflammation influencing transcription factors growth factors cytokines receptors and enzymes Clinical trials at Phase I reported no observed toxicity at doses up to 12 g/day however oral bioavailability is limited ( 1% in Phase I/II studies) Additionally curcumin demonstrates potential for Alzheimer s research as evidenced by reducing beta-amyloid (A 40 A 42) production via downregulating presenilin-1 and GSK-3 in SH-SY5Y neuroblastoma cells
eMolecules 2'-(4-Fluorobenzyloxy)acetophenone | 400878-24-2 | MFCD03001269 | 1g
Oakwood Chemical | 2'-(4-Fluorobenzyloxy)acetophenone | 1g | 537671485 | 010106 | | 400878-24-2 | MFCD03001269 | 244.265 | C15H13FO2
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eMolecules 501-98-4 | Trans-4-Hydroxycinnamic Acid | MFCD00004399 | 25g
Ambeed | Trans-4-Hydroxycinnamic Acid | 25g | 552634112 | A192873 | 501-98-4 | MFCD00004399 | 164.160 | C9H8O3
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Apexbio Technology LLC Tyrphostin AG 1296 146535-11-7 25mg
Tyrphostin AG 1296 (CAS 146535-11-7) is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) kinase via ATP-competitive binding Its inhibitory activity (IC50 0 3 0 5 M) results from inducing conformational changes in the ATP-binding domain of PDGFR blocking receptor autophosphorylation induced by ligand binding In vitro studies demonstrate inhibition of PDGF-stimulated mitogenesis (IC50 1 5 M) and cell proliferation (IC50 3 2 M) using Swiss 3T3 cells without significant effects on EGF receptor signaling at concentrations up to 100 M Tyrphostin AG 1296 serves as a research tool for investigating PDGFR-mediated signaling pathways
Medchemexpress LLC Trans-4-chlorocinnamic acid | 1615-02-7 | MFCD00004396 | >98.0% | 182.60 g/mol | C9H7ClO2 | 100g
4-Chlorocinnamic acid is a derivative of Cinnamic acid (HY-N0610A) 4-Chlorocinnamic acid inhibits the monophenolase and diphenolase activities of mushroom tyrosinase with IC50 values of 0 477 mM and 0 229 mM respectively 4-Chlorocinnamic acid inhibits the mycelial growth of Colletotrichum gloeosporioides 4-Chlorocinnamic acid exhibits anticonvulsant activity against acute epilepsy induced by pentylenetetrazol[1][2][3][4]